New Frontiers and Evolving Paradigms in Cancer and Thrombosis

Webcast CME Disclosure

Please read this notice and click the acknowledgement
at the bottom of the page to continue.

Program Medium:

Internet-based program

Method of Physician Participation Utilized in Learning Process:

There are no fees for participating and receiving CME credit for this activity. During the period June 18, 2011 through June 18, 2013 participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity; 3) register and complete the evaluation form; and 4) print out your CME certificate.

Estimated Time to Complete Educational Activity:

3.0 hours

Course Overview:

In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding of treatment advances in the prevention and management of thrombosis in the setting of cancer.

Release Date:

June 18, 2011

Expiration Date:

June 18, 2013

Intended Audience:

• Cancer Specialists
• Clinical Oncologists
• Hematologists and Thrombosis Specialists
• Oncology Program Directors
• Oncology-focused Pharmacists
• Nurse Oncologists
• Oncology-Focused Nurse Practitioners

Registration:

Enrollment for this WebCAST is complimentary, and clinicians are invited to participate in this CME-certified WebCAST and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support:

Supported by Independent Educational Grants
from sanofi-aventis

Disclosure of Conflicts of Interest:

It is the policy of the University of Massachusetts Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.

Accreditation Statement:

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Massachusetts Medical School Office of Continuing Medical Education (UMMS-OCME) and CMEducation Resources. The UMMS-OCME is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement:

The University of Massachusetts Medical School designates this enduring material for a maximum of 3.0 AMA PRA Category 1 Credits(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Program Faculty and Disclosures:

PROFESSOR LORD AJAY KAKKAR, MBBS (HONS) BSC, PhD, FRCS
(Program Chairperson)
Professor and Head
Centre for Surgical Science
Dean of External Relations
Barts and the London School of Medicine and Dentistry
London, UK

Nothing to disclose

FREDERICK R. RICKLES, MD, FACP
Professor of Medicine, Pediatrics and Pharmacology and Physiology
The George Washington University
Katzen Cancer Center
Medical Faculty Associates
Washington, DC

Consultant: Eisai, Genmab, Pharmacyclics, Ortho
McNeil (J&J)/Bayer
Speaker's Bureau: Eisai


ALOK A. KHORANA, MD, FACP
Vice-Chief, Division of Hematology/Oncology
Associate Professor of Medicine and Oncology
James P. Wilmot Cancer Center
University of Rochester
Rochester, NY

Consultant: Sanofi-Aventis, Eisai, LEO Pharma,
Daiichi Sankyo
Speaker's Bureau: Roche


CRAIG KESSLER, MD, MACP
Professor of Medicine and Pathology
Georgetown University Medical Center
Director, Division of Coagulation
Lombardi Comprehensive Cancer Center
Washington, DC

Consultant: Esai, Inc., Novo Nordisk
Grant/Research Suport: Novo/Nordisk

Program Managers and Web Editor Disclosure:

Program Manager Gideon Bosker, MD has nothing to disclose.

Program Reviewer Denise Leary has nothing to disclose.

Educational Objectives:

Upon completion of this activity, participants will:

1. Be better educated about established and evolving ASCO and NCCN algorithms and guidelines for screening, diagnosing, assessing, and implementing evidence-based treatment plans for patients with cancer
2. Be better educated about what pharmacologic interventions—including those affecting the coagulation system—can be implemented to prevent and/or treat thrombotic disorders in different tumor types, and what impact anticoagulation strategies may have on other end points in cancer, including survival and tumor progression
3. Have a better understanding the role activation of blood coagulation, and how tissue factor (TF)-rich microparticles (MPs) may be linked directly to oncogene-induced malignant transformation
4. Have a better understanding of the role of tissue factor antigen levels and attenuated induction of cellular invasion in patients with advanced cancers (i.e., pancreatic) and the usefulness of these assays as markers to guide appropriate use of LMWHs to optimize anticancer effects of agents affecting the coagulation cascade
5. Be better able to compare and analyze the safety, efficacy, costs of monitoring, and long-term outcomes of vitamin K antagonists versus LMWHs when managing cancer patients who require secondary prevention of VTE
6. Develop a more science-based understanding the mechanisms of thrombosis formation in cancer patients and the effects of established and investigational LWMHs and ULMWHs on inhibition of the coagulation cascade; on tumor growth; on patient outcomes; and on angiogenesis, apoptosis, and tumor spread
7. Be more clinically proficient at risk-stratifying and identifying indicated, LMWH-based therapies for VTE prevention that are consistent with NCCN, ASCO, ASH, and/or ACCP guideline
8. Have a more evidence-based understanding of what survival effects, if any, have been observed in cancer patients who have undergone established cancer treatment regimen, in conjunction with LMWH-based prophylaxis for thrombosis-related risk factors

Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to printout the CME certificate.

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• For each CME activity that you take, you must complete an evaluation questionnaire. That questionnaire asks if you are willing to participate in a follow-up survey. If you answer yes, we will use your name and contact information to send you the survey.
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Disclaimer:

Copyright © 2011 by CMEducation Resources, LLC All rights reserved.
Reproduction, distribution, or translation without express written permission is strictly prohibited.

Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity.
Content on this webcast is not meant to be, nor substitute for national guidelines or recommendations generated by professional, academic societies, colleges, or associations.

Content on this webcast is intended for educational value only. Its contents, analyses, and any recommendation made herein are intended to make scientific information and opinion available to health professionals, to stimulate thought, and further investigation. This webcast is not designed nor is any aspect of the contents here intended to provide advice regarding medical diagnosis or treatment for any individual case. Any decisions regarding diagnosis and/or management of any individual patient or group of patients should be made on individual basis after having consulted appropriate sources, whether they be appropriate consultants and/or guidelines and recommendations issued by national organizations, professional societies, governmental health organizations, or similar bodies. This webcast is not intended for use by the layman.

Opinions expressed herein are not necessarily those of CMEducation Resources, LLC, or the program supporters or accreditors, but reflect the opinions and analyses of the experts who have authored the material. Mention of products or services does not constitute endorsement. Clinical, legal, financial, and other comments are offered for general guidance only; and professional counsel should be sought for all specific situations.

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