ACS-WRAP:
Focus on Oral Antiplatelet Therapy
for Medical Management of ACS

MedicineWRAP CME Disclosure

Please read this notice and click the acknowledgement
at the bottom of the page to continue.

Program Medium:

Internet-based program

Method of Physician Participation Utilized in Learning Process:

There are no fees for participating and receiving CME credit for this activity. During the period December 12, 2011 through December 12, 2013 participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity; 3) register and complete the evaluation form; and 4) print out your CME certificate.

Estimated Time to Complete Educational Activity:

2.0 hours

Course Overview:

In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding of treatment advances in antiplatelet therapy for the management of acute coronary syndrome.

Release Date:

December 12, 2011

Expiration Date:

December 12, 2013

Intended Audience:

This program is intended for all cardiovascular-focused clinicians, investigators, program directors, and healthcare providers caring for patients with cardiovascular disease, ACS, and related conditions

Registration:

Enrollment for this WebCAST is complimentary, and clinicians are invited to participate in this CME-certified WebCAST and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support:

This activity is supported by an educational grant
from Bristol-Myers Squibb

Physician Continuing Education

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The University of Massachusetts Medical School, Office of CME and CMEducation Resources, LLC. The University of Massachusetts Medical School is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation

The University of Massachusetts Medical School designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure of Conflicts of Interest:

It is the policy of the University of Massachusetts Medical School to ensure fair balance, independence, objectivity, and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials

Program Faculty and Disclosures:

Charles V. Pollack, Jr., M.A., M.D., FACEP
Professor and Chairman, Emergency Medicine
Pennsylvania Hospital
University of Pennsylvania Health System
Philadelphia

Faculty Disclosures
Dr. Charles Pollack discloses that he has been a consultant to Bristol-Myers Squibb, The Medicines Company, sanofi-aventis, Genentech and Schering-Plough. He has received direct research support from GlaxoSmithKline, and has been a speaker for Schering-Plough, Bristol-Myers Squibb, and sanofi-aventis.

Advisory Board/Consultant: Amgen, Merck, Roche, Sanofi-aventis
Stockholder: Omthera Pharmaceuticals

Program Managers and Web Editor Disclosure:

Program Manager Gideon Bosker, MD has nothing to disclose.

Program Reviewer Denise Leary has nothing to disclose.

Educational Objectives:

Physicians, pharmacists, and other healthcare providers will:

• Be better educated about and more clinically proficient at implementing
  current ACC/AHA/ACEP/SCAI guidelines for management of UA/NSTEMI as
  these recommendations relate to use of antiplatelet and other antithrombotic
  agents in patients undergoing both acute and long-term medical
  management of UA/NSTE-ACS.
• Become more aware of the role that each clinical specialty group and
  stakeholder—emergency physician, hospitalist, primary care/internal
  medicine, cardiologist—has for ensuring guideline-adherent implementation
  of antiplatelet therapy at each phase of the medical management cycle for
  ACS, including ED, hospital, CCU, pre- and post-angiography, hospital
  discharge, and post-hospital, enduring medical management of ACS.
• Become more aware of the importance that multiple specialty groups
  involved in the ACS management cycle adhere to published, evidence-based
  guidelines as the core strategy for medical management of patients with
  ACS.
• Be better educated about and more clinically proficient at optimizing
  medical treatment of NSTE-ACS, based on proper risk stratification strategies
  which will help identify patients who are best treated with a conservative
  (medical) approach for UA/NSTEMI, in both the acute and long-term settings.
• Become more clinically skilled at identifying ACS patients who are
  amenable to a medical strategy for their treatment, and be better able to
  apply the results of landmark studies outlining how to implement a
  selectively invasive strategy for ACS, and what the impact is of medical-based
  strategies for ACS is one patient outcomes.
• Be better educated and better able to implement dosing and evidence-based
  guidelines for long-term antiplatelet management of ACS (UA and
  NSTEMI) patients who, based on risk stratification criteria or findings at
  angiography, are appropriate for a long-term medical strategy employing
  antiplatelet agents and other cardioprotective therapies.
• Be better educated, based on scientific evidence and clinical trial data, on
  how best to assess the need or suitability of medically managed ACS patients
  for specific genetic testing prior to antiplatelet therapy; and how to
  implement current, evidence-based standards of clinical practice endorsed by
  published guidelines, FDA, and Clinical Alerts issued by the ACCF/AHA.
• Be better educated and understand the implications and risks associated
  with suboptimal treatment of medical managed ACS, and the comparative
  outcomes of patients managed with appropriate doses and duration
  guideline-mandated oral antithrombotic/antiplatelet therapy versus those
  receiving suboptimal medical therapy for ACS.
• Be better educated about the foundation role of oral antiplatelet agents
  when managing acutely ill patients presenting to the ED or CCU with NSTEACS
  or STEMI, and more aware of guidelines and recommendations for
  continuing oral therapy in the post-hospitalization period.
• Be better able to implement optimal dosing, duration of therapy, and
  timing strategies for antiplatelet agents, i.e. putting into practice, at all
  phases of ACS care, those approaches that produce the best balance of
  thrombosis mitigating outcomes and bleeding safety, for oral antiplatelet
  agents in the setting of medical therapy for ACS
• Become more clinically skilled at initial risk stratification of patients
  presenting with UA or NSTE-ACS, as a basis for determining optimal,
  guideline-compliant approaches to antiplatelet therapy for initial and long-term
  post-ACS cardioprotection.
• Become more educated about the pathophysiology, mechanisms of action,
  resistance, pharmacokinetics, and pharmacodynamics of antiplatelet agents
  and how these factors should impact clinical therapeutics for medical
  managed patients with ACS, including PPI-antiplatelet therapy interactions.
• Become more skilled at interpreting and analyzing landmark trials and
  CRUSADE registry data in order to facilitate optimal drug selection, with a
  focus on implementing the optimal approach to timing, selection, dosing,
  combination therapy, and appropriate use of antiplatelet agents in the setting
  of NSTE-ACS and UA.
• Become more aware of the implications of the CRUSADE, DUKE, GRACE,
  and REACH registries and how they have helped identify and illuminate
  clinical practice gaps in medical management of patients with ACS.
• Better educated and skilled at applying AHA/ACC guidelines for
  management of NSTE-ACS and the Year 2008 STEMI Update, with a focus on
  timing of administration and special considerations for long-term antiplatelet
  therapy depending on risk stratification, invasive vs. non-invasive strategies,
  and CABG.
• Better educated about the pharmacology, dose, and side effects of
  antiplatelet agents employed for medical management of ACS.
• Become more proficient at prescribing strategies for antiplatelet agents that
  reduce side effects and increase the likelihood of optimal clinical outcomes in
  patients with ACS, including indications for using PPIs in combination with
  antiplatelet agents.
• Be better able to characterize and distinguish among safety profiles and
  bleeding risks and efficacy characteristics of oral antiplatelet agents used to
  medically manage ACS patients in the acute and long-term, post-ACS, post-hospitalization setting.
  

Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to printout the CME certificate.

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