Optimizing the Risk-Benefit Equation
for Multiple Sclerosis
Webcast CME Disclosure
Please read this notice and click the acknowledgement
at the bottom of the page to continue.
Estimated Time to Complete Educational Activity
In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding of treatment advances in multiple sclerosis
April 10, 2013
April 10, 2015
Method of Physician Participation Utilized in Learning Process
There are no fees for participating and receiving CME credit for this activity. During the period April 10, 2013 through April 10, 2015, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view all six segments totaling 3.5 hours to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out your CME certificate.
Participation in this WebCAST is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.
This CME activity is supported
by an educational grant from
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Complete Conference Management and CMEducation Resources, LLC. Complete Conference Management is accredited by the ACCME to provide continuing medical education for physicians.
Credit Designation Statement
Complete Conference Management designates this enduring material for a maximum of 3.5 AMA PRA Category 1 Credits(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Policy on Faculty & Provider Disclosure
It is the policy of Complete Conference Management to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by Complete Conference Management are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.
Program Faculty and Disclosure
THOMAS P. LEIST, MD, PhD – Program Chairman
Thomas Jefferson University
Director Comprehensive MS Center
Research Support: Sanofi, Sun Pharma, Novartis, Roche
Speaker Honoraria; Teva Neuroscience, Sanofi, Novartis
Consultant/Advisory Board: Teva Neuroscience, Novartis, Biogen-Idec, Bayer, Sanofi,
BURK JUBELT, MD
Professor of Neurology, Microbiology/Immunology and Neuroscience
SUNY Upstate Medical University
Research Support: Sanofi-Aventis Clinical Trials, Genzyme Clinical Trial, Biogen Clinical Studies, Novartis Clinical Trial
Consultant/Advisory Board: Biogen Clinical Studies, National MS Society, Upstate NY Chapter, MS Resources of Central NY
M. TARIQ BHATTI, MD
Associate Professor, Neuro-Ophthalmology
Departments of Ophthalmology and Medicine (Division of Neurology)
Duke University Eye Center and Duke University Medical Center
Durham, North Carolina
Speaker/Honoraria: EMD Serono, Pfizer, Novartis, Bayer Healthcare
Consultant/Advisory Board: Novartis
DANIEL KANTOR, MD
Ponte Vedra, FL
Research Support: Acorda, Avanir, Allergan, Merz, Medicis, US World Meds,
Genzyme, Questcor, Novartis, Osmotica, Teva, Biogen
Speaker/Honoraria: Acorda, Avanir, Allergan, Merz, Medicis, US World Meds,
Genzyme, Questcor, Novartis, Osmotica, Teva, Biogen,
Consultant/Advisory Board: Acorda, Avanir, Allergan, Merz, Medicis, US World Meds,
Genzyme, Questcor, Novartis, Osmotica, Teva, Biogen
Program Managers and Web Editor Disclosure
Program Manager Gideon Bosker, MD has nothing to disclose.
Program Reviewer Denise Leary has nothing to disclose.
Upon completion of this activity, participants will be able to:
- Identify the rationale for treating patients with MS with established injected agents shown to act through immunomodulating effects and actions that take place in the central nervous system;
- Explain the role of established injectable neuroimmunomodulating agents, the evolving role of oral neuroimmunomodulating agents for MS; and, how such agents, including established injectable IMTs, acting on both inflammatory and neurodegenerative dimensions of MS disease progression, may produce different clinical outcome end points, including improvements in EDSS and other disability end points, than agents acting on inflammatory dimensions of the disease only;
- Detail the variable actions and safety profiles of oral and injectable MS agents, including injectable IMTs, and develop a better and more scientifically rigorous appreciation for the difference among "anti-inflammatory" and "neuroprotective" properties of such agents; and their effects on such clinical end points as relapse rate, disability metrics, core health outcomes, and neuroimaging manifestations of neurodegeneration;
- Understand when, how, and if to make cross-trial comparisons among oral and injectable immune-modulating agents for MS, and how to interpret the findings of clinical trials with multiple primary and secondary end points and compare those findings to the LTFU data available for established platform injectable therapies;
- Understand the mechanistic differences and safety profiles among oral and injectable agents that are effective for reducing relapse rates versus those that have primarily or complementary neuroprotective properties as evidenced by change in MRI neurometrics, cerebral atrophy, and improved disability scales.
Hardware and Software Requirements:
To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.
When you participate in a CME activity offered by CMEducation Resources, we ask you for your name, degree, affiliation, street address, telephone number, fax number, and/or e-mail address (the "Information"). We use that Information in the following ways:
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- For each CME activity that you take, you must complete an evaluation questionnaire. That questionnaire asks if you are willing to participate in a follow-up survey. If you answer yes, we will use your name and contact information to send you the survey.
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Copyright © 2013 by CMEducation Resources, LLC All rights reserved.
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Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity.
Content on this webcast is not meant to be, nor substitute for national guidelines or recommendations generated by professional, academic societies, colleges, or associations.
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