Direct Thrombin and Factor Xa   Inhibition for SPAF


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Webcast CME Disclosure

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Program Medium

Internet-based program

Estimated Time to Complete Educational Activity

3.0 hours

Course Overview

In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding and management of stroke prevention in atrial fibrillation

Release Date

November 11, 2013

Expiration Date

November 11, 2015

Method of Participation

There are no fees for participating and receiving CME credit for this activity. During the period November 11, 2013 through November 11, 2015, participants must: 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view all 7 segments totaling 3.0 hours to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out your CME certificate.


Participation in this WebCAST is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support


This CME activity is supported by an educational grant from Boehringer Ingelheim

Accreditation Statement

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Complete Conference Management and CMEducation Resources, LLC. Complete Conference Management is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

Complete Conference Management designates this enduring material for a maximum of 3.0 AMA PRA Category 1 Credits(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Policy

In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards for Commercial Support, educational programs sponsored by University of Massachusetts Medical Center and Complete Conference Management must demonstrate balance, independence, objectivity, and scientific rigor. All faculty, authors, editors, staff, and planning committee members participating in a University of Massachusetts Medical Center and CCM-sponsored activity are required to disclose any relevant financial interest or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity.

Program Faculty and Disclosure

Program Chairman
Director, Venous Thromboembolism Research Group
Cardiovascular Division
Brigham and Women’s Hospital
Professor of Medicine
Harvard Medical School
Boston, MA

Consultant: Baxter, Boehringer Ingelheim, Bristol Myers Squibb,
Daiichi Sankyo, Eisai, Merck, Pfizer, Portola, Sanofi Aventis
Grant/Research Support: Daiichi Sankyo, Eisai, EKOS, J&J, Sanofi Aventis

Associate Physician
Cardiovascular Division
Brigham and Women’s Hospital
Instructor in Medicine
Harvard Medical School
Boston, MA

Grant/Research Support: Daiichi-Sankyo (Investigator of AF Trial)

Professor of Medicine
Duke University Medical Center
Directory, Cardiac Care Unit
Duke University Medical Center
Durham, NC

Consultant: Boehringer Ingelheim, Bristol Myers Squibb, GSK, Hoffmann-LaRoche,
Lilly, Pfizer, Sanofi-aventis, Takeda, The Medicines Company,
Astra Zeneca, Daiichi Sankyo, Ross Medical Corporation
Research Grants: Boehring Ingelheim, Bristol Myers Squibb, GSK, Medtronic Foundation,
Merck & Co., Pfizer, Sanofi-aventis, Takeda, The Medicines Company

Program Managers and Web Editor Disclosure

Gideon Bosker, MD - Program Reviewer and Planning Committee: Nthing to disclose.

Milo Falcon - Planning Committee: Nothing to disclose

Kelly Kraines- Planning Committee: Nothing to disclose

Educational Objectives

Upon completion of this activity, participants will be able to:

  • Detail advances in oral anticoagulation based on new mechanisms involving inhibition of targeted factors in the coagulation cascade; and the possible implications of these advances for prophylaxis of arterial thromboembolism and stroke in the setting of atrial fibrillation
  • Apply national guidelines—including those issues by the ACC, AHA, ASA, ACCP, and others—so that they can overcome practice gaps and improve thrombosis management and clinical outcomes in patients with AF and other risk factors for stroke
  • Understand how systemic anticoagulation with established and novel, non-monitored anticoagulants (NMOACs), when aligned with specific risk scores for AF, including CHADS2, CHA2DS2-VASc, and HAS-BLED, can reduce risk of stroke in the setting of AF; and, as a result become more clinically skilled at using multiple approaches, including established VKA-based treatment, and new, evidence-based, guideline-sanctioned approaches affecting other targets in the coagulation cascade
  • Describe the epidemiology, scope of problem, risk stratification (CHADS2), landmark trials, national guidelines, and the multidimensional therapeutic landscape of antithrombotic strategies shown to be useful for stroke risk reduction in AF; and, as result, become more clinically skilled at intervening in appropriately risk-stratified patients, in order to improve clinical outcomes in patients at risk of stroke in the setting of AF
  • Detail the mechanisms involved in thromboembolic prevention in AF, and how new agents employing these mechanisms, with predictable anticoagulation, in the absence of clinical monitoring, fit into the treatment algorithms for SPAF

Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.

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  • For each CME activity that you take, you must complete an evaluation questionnaire. That questionnaire asks if you are willing to participate in a follow-up survey. If you answer yes, we will use your name and contact information to send you the survey.
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Copyright © 2013 by CMEducation Resources, LLC All rights reserved.

Reproduction, distribution, or translation without express written permission is strictly prohibited.

Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity.

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Key Program Topics Include:

ACC/AHA/ESC Guidelines
Atrial Fibrillation


Factor Xa Inhibitor
Intracerebral Hemorrhage
Myocardial infarction
Pulmonary embolism

RE-LY Trial
rhythm control
Valvular Atrial Fibrillation