Challenges in Pharmacologic Management of Primary Generalized Tonic-Clonic Seizures (PGTC) and Partial-Onset Seizures (POS)


Webcast CME Disclosure

Please read this notice and click the acknowledgement
at the bottom of the page to continue.

Program Medium

Internet-based program

Estimated Time to Complete Educational Activity

3.5 hours

Course Overview

In this web-based program, physicians will learn how recent advances in basic and clinical research have helped to advance the understanding of treatment advances in epilepsy.

Release Date

May 12, 2015

Expiration Date

May 12, 2017

Method of Physician Participation Utilized in Learning Process

There are no fees for participating and receiving CME credit for this activity. During the period May 12, 2015 through May 12, 2017, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity, and are expected to view all 8 segments totaling 3.5 hours to successfully complete the activity and earn CME credit; 3) register and complete the evaluation form and post-test; 4) score 100% on the post-test; and 5) print out your CME certificate.


Participation in this WebCAST is complimentary, and clinicians are invited to view this CME-certified program and/or share this invitation with other colleagues, departmental staff members, and healthcare professionals.

Grantor Support

Supported by an educational grant from Eisai, Inc.

Accreditation Statement

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Massachusetts Medical School and CMEducation Resources, LLC. The University of Massachusetts Medical School is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement

The University of Massachusetts Medical School designates this enduring material for a maximum of 3.5 AMA PRA Category 1 Credits(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Policy on Faculty & Provider Disclosure

It is the policy of the University of Massachusetts Medical School to ensure fair balance, independence, objectivity and scientific rigor in all activities. All faculty participating in CME activities sponsored by the University of Massachusetts Medical School are required to present evidence-based data, identify and reference off-label product use and disclose all relevant financial relationships with those supporting the activity or others whose products or services are discussed. Faculty disclosure will be provided in the activity materials.

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.
American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.
American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credits™ from organizations accredited by the ACCME.

Program Faculty and Disclosure

Program Chairman
Chief, Department of Neurology
Miami Children’s Hospital
Assistant Professor, Department of Neurology
University of Miami Miller School of Medicine
Miami, FL

Consultant and Speaker’s Bureau: Eisai, Lundbeck, Supernus

Professor of Neurology
Barrow Neurological Institute
Phoenix, AZ

Consultant: Eisai, Lundbeck, UCB
Speaker’s Bureau: Eisai, Lundbeck, UCB, Sunovion
Grant/Research Suport: Lundbeck, UCB, Upsher-Smith, SK Life Science

Washington University in St. Louis
The Epilepsy Center at Barnes-Jewish Hospital
St. Louis, MO

Consultant: Upsher-Smith Pharmaceuticals
Grant/Research Support: Upsher-Smith Pharmaceuticals, Eisai

Program Managers and Web Editor Disclosure

Program Manager Gideon Bosker, MD has nothing to disclose.

Program Reviewer Denise Leary has nothing to disclose.

Educational Objectives

Upon completion of this activity, participants will be able to:

  • Detail the mechanisms of action, novel targets, and the use of combination AED-based strategies for PGTCS and POS that are supported by evidence, clinical trials, and guidelines for managing refractory seizures in the setting of PGTCS and POS;
  • Outline the epidemiology, medical burden, and natural history of partial onset seizures (POS) with a focus on clinical dilemmas, refractory seizures, pharmacoresistance, and new therapeutic paradigms to optimize seizure freedom in patients with PGTCS and POS;
  • Explain the role and potential clinical usefulness of neuroreceptors and synaptic targets involved in neuronal excitation, including the role of potassium channel agonists, voltage-dependent sodium channels, and intracellular calcium fluxes in triggering or sustaining seizure activity;
  • Manage case studies in PGTCS and POS with refractory seizures to become more clinically proficient in sequencing, switching, and/or combining established, traditional AEDs with agents that produce therapeutic effects through novel mechanisms;
  • Apply the results and findings from landmark clinical and therapeutic trials in PGTCS and POS, including the role of so-called “third generation” agents that effect novel targets and, therefore, can be used as adjunctive therapy in patients with POS and refractory seizures;

Hardware and Software Requirements:

To participate in this program, viewers must have a PC or Macintosh computer that has active, ongoing internet access for the duration of the program, as well as a compatible Flash-viewer. An email address is required for registration, and a printer is required to print out the CME certificate.

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  • We use the Information to grade your post-test and to send you a certificate of completion of the CME activity. If we use a third-party company to grade your post-test and issue certificates of completion, we will give the Information to that company for that purpose only.
  • For each CME activity that you take, you must complete an evaluation questionnaire. That questionnaire asks if you are willing to participate in a follow-up survey. If you answer yes, we will use your name and contact information to send you the survey.
  • We may use the Information to send you information about other CME activities that CMEducation Resources is offering.
  • If our company is acquired by or merged into another company, we may make the Information available to the new owner/entity to use in the ways described above, to enable it to continue our business.
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Copyright © 2015 by CMEducation Resources, LLC All rights reserved.

Reproduction, distribution, or translation without express written permission is strictly prohibited.

Content on this webcast reflects the opinions, output, and analyses of experts, investigators, educators, and clinicians whose activities for, while independent, are commercially supported by the sponsor noted at the start of each activity.

Content on this webcast is not meant to be, nor substitute for national guidelines or recommendations generated by professional, academic societies, colleges, or associations.

Content on this webcast is intended for educational value only. Its contents, analyses, and any recommendation made herein are intended to make scientific information and opinion available to health professionals, to stimulate thought, and further investigation. This webcast is not designed nor is any aspect of the contents here intended to provide advice regarding medical diagnosis or treatment for any individual case. Any decisions regarding diagnosis and/or management of any individual patient or group of patients should be made on individual basis after having consulted appropriate sources, whether they be appropriate consultants and/or guidelines and recommendations issued by national organizations, professional societies, governmental health organizations, or similar bodies. This webcast is not intended for use by the layman.

Opinions expressed herein are not necessarily those of CMEducation Resources, LLC, program supporters or accreditors, but reflect the opinions and analyses of the experts who have authored the material. Mention of products or services does not constitute endorsement. Clinical, legal, financial, and other comments are offered for general guidance only; and professional counsel should be sought for all specific situations.




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Key Program Topics Include:

Anti-Epileptic Drug
Dravet Syndrome



Partial Seizures

Ring Chromosome 20